Wario is a main antagonist in the Mario series. He is rivals with Mario and Luigi and is brothers with Waluigi. He makes MicroGames as a profession, as seen in the WarioWare games. He is also enemies with Captain Syrup, a pirate who fights him in Super Wario Land 3: Wario Land.
Super Smash Bros
Wario is a playable character and main antagonist in Super Smash Bros. Brawl. In SSBB he is able to control his farts, ride his WarioBike, and turn into WarioMan, his super form. He seems to be working for Master Hand, just like Bowser and Ganondorf. He attacks Ness and Lucas, and later attacks Lucas and Pokémon Trainer. He helps all the other smashers defeat Tabuu.