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- Vincent Price as Professor Ratigan: Basil's archenemy. He is based on Professor James Moriarty from the Sherlock Holmes stories. He plots to seize control of the British monarchy. He and Basil are long-established archenemies. In the book series, it is revealed his given name is Padraic and that Ratigan is, in fact, a mouse. At the end of the film, he is knocked off Big Ben and disappears into the fog below, following a fierce battle with Basil, similar to the Sherlock Homes story "The Final Problem".
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