Her first appearance was in "Tobey's Tricks and Treats". In this episode, while Violet dressed up as WordGirl for Halloween, Priscilla, who was referred to then as "Fluffy", was dressed in a Captain Huggyface costume.
Notably, Priscilla is the only animal, along with Captain Huggy Face, known to be aware of WordGirl's secret identity. Also in "Tobey's Tricks and Treats", Becky changed into WordGirl while holding her, much to the cat's surprise.
In the episode "Who Wants Candy?", Priscilla accompanied Violet, Becky, Bob, and the rest of the class on a field trip to Zachary Zany's Candy Factory.
Priscilla has been the subject of more than one of Violet's paintings. For example, in Lady Redundant Woman Gets the Blues, she was portrayed as the Mona Lisa. in Art's Parts, she was the center of a painting reminiscent of Boticelli's "The Birth of Venus."