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"I think that if I'm gonna be a secret agent, I should have a better name. I was thinking: Toto Annihilation!"
Lou is the main protagonist of Cats & Dogs, and a supporting character in Cats & Dogs: Revenge of Kitty Galore. He is an adopted pet of the Brody family.
He is voiced by Tobey Maguire in the first film, who also portrayed Spider-Man, and by Neil Patrick Harris voices him in the second film.