Itachi Uchiha is Sasuke's older brother, Sakura's brother-in-law, and also Sarada's paternal uncle. Most importantly, he is also the eldest son of the late Fugaku Uchiha and Mikoto Uchiha. He is voiced by Crispin Freeman in the American English dub, who also voiced Alucard from Hellsing.
- Fugaku Uchiha (father, deceased)
- Mikoto Uchiha (mother, deceased)
- Sasuke Uchiha (younger brother)
- Sakura Uchiha (sister-in-law)
- Sarada Uchiha (niece)
- Kizashi Haruno - His sister-in-law's father, his younger brother's father-in-law, and also his niece's maternal grandfather.
- Mebuki Haruno - His sister-in-law's mother, his younger brother's mother-in-law, and also his niece's maternal grandmother.