Del Meeko was a human male native of Coruscant, the capital world of the Galactic Empire during the Imperial Era. During the reign of Emperor Sheev Palpatine, Meeko served in the Imperial Military as a stormtrooper, a shoretrooper with the military rank of sergeant, an Imperial Starfighter Pilot, and subsequently as the chief engineer of a Star Destroyer when holding the rank of Lieutenant Commander. Following the Rebel Alliance's theft of the plans to the Death Star in the year 0 BBY, Meeko became an agent of Inferno Squad, a special forces unit led by Captain Iden Versio.
The Emperor's death in 4 ABY resulted in the activation of Operation: Cinder; as part of the overall Contingency, its purpose was to ensure the annihilation of both the Empire and its enemies. Inferno Squad was dispatched to Fondor with orders to retrieve satellites that were critical to the execution of Operation: Cinder. After completing their mission, Meeko was ordered to destroy the Emperor's Observatory on Pillio. In the course of his mission, he encountered the Jedi Knight Luke Skywalker. Despite their different allegiances, Meeko and Skywalker worked together by fighting off many scritters—indigenous lifeforms that were hostile to the offworlders—in order to reach the observatory.
After parting ways with Skywalker, Meeko rejoined Inferno Squad at Vardos where the team learned that Versio's homeworld was one of the targets under Operation: Cinder. Unwilling to participate in the ruin of a planet noted for its loyalty to the Empire, Meeko and Versio rebelled against the military in an effort to save civilians. Having severed their ties with the Empire, they surrendered to the Alliance, but were given a chance to fight alongside the Rebels at the Battle of Theed. By saving Naboo, another planet targeted by Operation: Cinder, Meeko and Versio were both welcomed into the ranks of the newly-formed New Republic by Princess Leia Organa.
In 5 ABY, approximately one year after the Battle of Endor, the new Inferno Squad was among the Republic forces that defeated the Imperial forces led by Counselor Gallius Rax at the Battle of Jakku. In the years that followed the Empire's defeat and the conclusion of the Galactic Civil War, Meeko and Versio raised a daughter named Zay Versio. Decades after the war, Meeko was captured by the First Order and interrogated by Kylo Ren, a dark side warrior tasked with hunting the last Jedi. With no further use for Meeko, Ren turned the veteran soldier over to Commander Gideon Hask—a First Order officer who once served with Meeko as an agent of Inferno Squad—who personally executed his former comrade.