Charlotte Pickles is the mother of Angelica Pickles, the wife of Drew Pickles, the sister-in-law of Stu Pickles, the daughter-in-law of Lou Pickles and the late Trixie Pickles (nee McGee), and also the stepdaughter-in-law of Lulu Pickles. She was voiced by Tress MacNeille, who also voiced Anastasia Tremaine in Disney's Cinderella film series and Grandma Gertie in Hey Arnold.
- Drew Pickles (husband)
- Angelica Pickles (daughter)
- Stu Pickles (brother-in-law)
- Lou Pickles (father-in-law)
- Trixie Pickles (mother-in-law, deceased)
- Lulu Pickles (stepmother-in-law)