Characters who are villainous antagonists that do mean, selfish, cruel and evil things. Characters who are antagonists of their selected medium. A list of main antagonists and villains in their video game(s), film(s), manga (s), anime (s), comic book(s), and show(s).
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A
- A (Pretty Little Liars)
- A. B. C-more
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- ABC Crab
- Abominable snow molusk
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- Abraslam Lincoln
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- Acer and Grem
- Adolf Hitler
- Adolf Hitler (Fullmetal Alchemist)
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- Adonis (Ren & Stimpy)
- Adrian Graye Vernworth
- Adrienne
- Aeon the Terrible
- Agent Trout
- Aggie (Craig of the Creek)
- Aggressive Monster Elmo
- Aircraft Carrier Princess
- Aku
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- Al McWhiggin
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- Alastor (Hazbin Hotel)
- Albert Contiello
- Albert Einstein (ERB)
- Albert Wesker
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- Alejandro Burromuerto
- Alejandro Gutierrez
- Alex (Loo Loo Kids)
- Alexander Minion
- Ali
- Ali (Friday the 13th)
- Aliana (Pokémon)
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- Aliens (Chicken Little)
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- Alois Trancy
- Alucard (Rosario+Vampire)
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- Amalgamuppet
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- Amazing Rope Guy
- Amber Whitmire
- Ammo Baron
- Amoeba Boys (Powerpuff Girls Z)
- Amon (Kirby)
- Amy (Total Drama)
- Android 16
- Android 19
- Angela Li
- Angelica Pickles
- Anglerfish (Finding Nemo)
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- Annie Leonhart
- Announcer (BFDI)
- Anthony DeMartino
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- Anti-Pops
- Anti-Virus Bots
- Apex Seelkadoom
- April Smuntz
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- Archer (Pokémon)
- Archibald Snatcher
- Archie (Pokémon)
- Aria Blaze
- Ariana (Pokémon)
- Arich
- Armless Man
- Arnold the Pit Bull
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- Arrow
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- Arty Alligator
- Asmodeus (Helluva Boss)
- Astrid the Ugly (Duck Dodgers)
- Atlantean (Unclassified Encounter)
- Aumsum(It's AumSum Time)
- Aunt Grandma
- AUTO (WALL•E)
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- AwesomeAlfonso13
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- Azrael
B
- Baby Doll (White Knight)
- Baby Sinclair
- Backson (Winnie the Pooh)
- Bad Bill
- Bad Cop
- Balloon Boy
- Ballora
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- Balthazar (Rango)
- Balthazar Bratt
- Banbaleena
- Bane
- Bane (The Lego Batman Movie)
- Banzai
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- Barkis Bittern
- Baron Draxum
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- Baron von Cavitus
- Baron Von Sheldgoose
- Barracuda (Finding Nemo)
- Bart and Eddie
- Barty Crouch Jr.
- Bat (Kemy)
- Battle Droids
- Baxter (Back at the Barnyard)
- Baxter Stockman (TMNT 1987)
- Baylan Skoll
- Bear (AppuSeries)
- Bear (ARPO The Robot)
- Bear (Barney & Friends)
- Bear (Barney & Friends: At Home with Animals)
- Bear (Barney & Friends: Barney's Musical Castle)
- Bear (Kemy)
- Bear (Kidsongs)
- Bear (The Singing Walrus)
- Bears (Elmo's World)
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- Beavis
- Bebop and Rocksteady
- Belladonna
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- Belle Bottom
- Bellman
- Ben Chang
- BEN Drowned
- Bendy (Foster’s Home for Imaginary Friends)
- Bernie Kropp
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- Bianca Dupree
- Bibbo
- Biff Tannen
- Big Baby
- Big Bad Wolf (Green Jellÿ)
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- Big Bayou
- Big Bull Demon
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- Big Jet
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- Big Show (The Jetsons & WWE: Robo-WrestleMania!)
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- Biker in Black
- Bill Bluff
- Bill Cipher
- Bill Sykes
- Billiam Milliam
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- Bingo (Little Baby Bum)
- Bingo (The Banana Splits Movie)
- Binky Barnes
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- Bird Brain
- Bittergiggle
- Bla Bla Bla/Dog Power
- Black (Rainbow Friends Logic)
- Black Arts Beagle
- Black Cat (Kidsongs)
- Black Cat (KidsTV123)
- Black Knight Ghost
- Black Krrsantan
- Black Powder (Pucca)
- BlackJack SquarePants
- Blaineley
- Blaze
- Blitzo
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- Blue (Rainbow Friends)
- Blue Diamond
- Bluff
- Bob
- Bob Burrows
- Boba Fett
- Bobby Ganoush
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- Bomb Voyage
- Bonnie the Bunny
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- Boomer
- Boq (Unclassified Encounter)
- Boris Badenov
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- Boris the Wolf
- Boshi