Serial Killers are people who murder at least three people (or, in some extremely rarer cases, two people) over a period, with "cooling off" periods. They may be obsessed with a certain topic or target a specific group of people, and usually kill their victims in similar ways.
Most serial killers live a seemingly normal life when not engaging in murder. They can also be called serial killers if they use the same method each time. In addition, most (if not all) serial killers are highly intelligent, strategical, slippery, and very good liars and manipulators, as well as charming and seductive. Therefore, they are very difficult to catch, even for police.
In many cases, the best way to catch a serial killer is with the help from another serial killer, since they are the only people who know how another serial killer operates.
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- Sam (Trick 'r Treat)
- Sandor Clegane
- Satan (Blue Exorcist)
- Savage Opress
- Scarlett (Total Drama)
- Selim Bradley
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- Sharky
- Shaw
- Sheila Broflovski
- Shorty
- Shredder (2012 TMNT)
- Shuu Tsukiyama
- Siren Sara
- Six-Shooter
- Slam
- Slim (Killer Klown)
- Sorath
- Spikey
- Stewart Rudich (MDickie)
- Stewie Griffin
- Storefront
- Stormfront
- Sweeney Todd (The Demon Barber of Fleet Street)
- Sweet Tooth
- Syndrome
- Tall Man
- Talls
- Tempest Shadow
- Tetsuo Shima
- The Collection
- The Crazed Butt Stabber
- The Darkness (House on Haunted Hill)
- The Doctor (Dead by Daylight)
- The Dolls of Anapa
- The Entity (Wes Cravens New Nightmare)
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- The Hag (Dead by Daylight)
- The Hillbilly (Dead by Daylight)
- The Huntress (Dead by Daylight)
- The Joker
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- The Mimic
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- The Nurse (Dead by Daylight)
- The Trapper (Dead by Daylight)
- The Wraith (Dead by Daylight)
- Thomas LeBlanc
- Thrax (Osmosis Jones)
- Tito Turtle
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- Torch
- Trevor Phillips
- Tyrannosaurus Rex