Characters who get possessed or Brainwashed by the villain at least once. Alternativly they can still be good and possessed or brainwashed at the same time.
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- Sabrina Raincomprix
- Sailor Chibi Moon
- Sailor Neptune
- Sailor Pluto
- Sailor Saturn
- Sailor Uranus
- Sam Manson
- Sandy Cheeks
- Sayori
- Scootaloo
- Scorch (Star Wars)
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- Shana (Shakugan no Shana)
- Shauna Krawly
- Sheriff Graham
- Shining Armor
- Sleepy (Once Upon a Time)
- Sneezy (Once Upon a Time)
- Snow White (Once Upon a Time)
- Soldier Sky (Tank Lily Team)
- Sonia Nevermind
- Spider-Man
- Spider-Man (Tobey Maguire)
- Spike (My Little Pony: Friendship is Magic)
- Squaridot
- Squirt (Camp Lakebottom)
- Star-Lord (Marvel Cinematic Universe)
- Starlight Glimmer
- Stella (Angry Birds)
- Steve Freeling
- Stiles Stilinski
- Sunset Shimmer
- Super Stew
- Sweetie Belle
- Sydney Drew