Artificial Intelligence

Artificial Intelligences, or A.I.s for short are usually beings with a non-biological and inorganic form of self-awareness. They can be either technology-based (from programs or viruses and so on inhabiting a processor and/mechanical husk), magic-based (sentient mystical constructs such as golems or objects endowed with varying degree of sentience via. advanced spells), or combination of both.

Such villains are not always in mechanized forms but still living beings in their own rights. In fiction, they are usually created by biological entities but rebel against their creators. Sometimes these computers and their programs aren't evil but doing what they were programmed for (i.e. AUTO).

By definition, most of these count as Genderless regardless of the form(s) they take.