It was November 18, 1998. The Powerpuff Girls first aired on Cartoon Network. From that day on, everyone started loving the series (until that 2016 reboot). In Spacejamstr's version, The Powerpuff Girls first met 1998 Cartoon Network (Spacejamstr's version). From 1998 to 2013, Cartoon Network and the Powerpuff Girls were best friends.